Important Safety Information for NAD+

Important Safety Information for NAD+

Overview: NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that plays a critical role in energy production, DNA repair, and cellular metabolism. It is administered therapeutically via injection or IV infusion to support cellular health, energy levels, and healthy aging as natural NAD+ levels decline with age.

General Safety Information

NAD+ therapy is generally well tolerated when administered under medical supervision. Most side effects are mild and temporary, resolving shortly after treatment. However, individual responses may vary, and proper administration technique is important for minimizing discomfort.

Common Side Effects

  • Injection site reactions: pain, redness, swelling, or bruising
  • Mild nausea or stomach discomfort
  • Flushing or warmth in the face and chest
  • Fatigue or drowsiness following treatment
  • Headache
  • Muscle cramping or achiness

Less Common Side Effects

Some individuals may experience:

  • Dizziness or lightheadedness
  • Anxiety or jitteriness (particularly with rapid IV administration)
  • Chest tightness or pressure (typically with IV infusion)
  • Metallic taste in mouth
  • Difficulty sleeping if administered late in the day
  • Temporary increase in heart rate
  • Brain fog or difficulty concentrating (usually temporary)

If any of these symptoms persist or worsen, contact your healthcare provider.

Serious Risks and Warnings

While rare, the following should be monitored:

  • Rapid IV infusion can cause significant discomfort including chest tightness, shortness of breath, or severe nausea. IV NAD+ should always be administered slowly and under medical supervision
  • Allergic reactions may occur. Seek immediate medical attention for symptoms such as severe rash, swelling, difficulty breathing, or anaphylaxis
  • Individuals with kidney or liver dysfunction should use caution and may require adjusted dosing or additional monitoring
  • Electrolyte imbalances may occur with frequent high-dose treatments
  • Those with a history of gout should monitor uric acid levels, as NAD+ metabolism may influence purine pathways

Contraindications

NAD+ therapy should not be used in the following cases:

  • Known hypersensitivity to NAD+ or its components
  • Pregnancy or plans to become pregnant (insufficient safety data)
  • Breastfeeding (insufficient safety data)
  • Active severe kidney or liver disease without medical clearance
  • Uncontrolled metabolic disorders

Drug Interactions

NAD+ may interact with:

  • Chemotherapy agents, which may have altered effectiveness
  • Blood pressure medications, particularly with rapid infusion affecting cardiovascular response
  • Supplements containing niacin or nicotinamide, which may affect NAD+ metabolism
  • Alcohol, which should be avoided around treatment times as it depletes NAD+ levels

Always inform your healthcare provider of all medications, supplements, and herbal products you are taking.

Pregnancy and Breastfeeding

NAD+ therapy is not recommended during pregnancy or while breastfeeding. Safety in these populations has not been established. Consult your healthcare provider before use if you are pregnant, planning to become pregnant, or breastfeeding.

Storage Instructions

  • Injectable NAD+: Store refrigerated at 2–8°C (36–46°F). Do not freeze. Protect from light.
  • Once reconstituted, use within the timeframe specified by your provider (typically 30 days when refrigerated)
  • IV solution: Follow specific storage instructions provided by your healthcare facility

Keep out of reach of children. Do not use after the expiration date printed on the packaging.

Usage Guidelines

  • IV infusion: Should always be administered slowly over 2-4 hours under medical supervision to minimize side effects
  • Subcutaneous injection: Follow proper injection technique and rotate injection sites
  • Hydration: Drink plenty of water before and after treatment
  • Timing: Some patients prefer morning administration to avoid potential sleep disruption
  • Frequency: Typical protocols range from weekly to monthly treatments, depending on individual needs and treatment goals
  • Initial treatments may cause more pronounced side effects that often diminish with regular use

Administration-Specific Notes

For IV NAD+:

  • Infusion rate should start slowly and can be adjusted based on tolerance
  • Notify your provider immediately if you experience chest tightness, severe nausea, or difficulty breathing during infusion
  • Plan for 2-4 hours for complete administration

For Injectable NAD+:

  • Use proper sterile technique
  • Rotate injection sites to prevent tissue damage
  • Subcutaneous absorption may cause temporary discomfort at injection site

Consultation

For questions regarding dosing, administration methods, side effects, or treatment protocols, consult your healthcare provider.

Disclaimer

This information is intended for educational purposes only and does not substitute professional medical advice. The product has not been evaluated by the Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease.